The translocation t(1;19)(q23;p13) (TCF3/PBX1 fusion) is the most common recurrent genetic abnormality detected amongst patients with B-cell lymphoblastic leukaemia in Johannesburg, South Africa
نویسندگان
چکیده
Background: B-cell lymphoblastic leukaemia (B-ALL) is a malignancy of immature B-cells with several described recurrent genetic abnormalities. These have distinct clinico-pathological associations and show regional variation in prevalence. In all previously reported series, the translocation t(1;19) uncommon, comprising 40 years age, but also 8.1% children. Crude survival rates were overall poor (44.6% 57.4% patients < 18 age). On analysis, older KMT2A-rearrangement independently associated relapse-related death. The t(9;22) was not mortality from age. Conclusion: B-ALL shows pattern leukaemia-associated chromosomal translocations Johannesburg.
منابع مشابه
Diversity of T-cell receptor Gene Rearrangements in South Indian Patients with Common Acute Lymphoblastic Leukemia
Background: Precursor B-Acute Lymphoblastic Leukemia (precursor B-ALL) oc-curs due to the uncontrolled proliferation of B-lymphoid precursors arrested at a par-ticular stage of B-cell development. Precursor-B-ALL is classified mainly into pro-B-ALL, common-ALL and pre-B-ALL. The Common Acute Lymphoblastic Antigen CD10 is the marker for common-ALL. Objective: This study was aimed to examine the ...
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over time with transplant is not warranted. A portion of the sample REFERENCES did stay the same or better, and half were in the average range of 1. Peters C, Balthazor M, Shapiro EG, King RJ, Kollman C, intelligence at outcome on the Stanford Binet Intelligence Scale or Hegland JD, Henslee-Downey J, Trigg ME, Cowan MJ, Sanders J, McCarthy Scales of Children’s Abilities. We also note that, in t...
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Translocations involving the immunoglobulin heavy chain locus (IGH@) at chromosome band 14q32 are common in mature B-cell neoplasms, but are rare in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Here, we report the translocation, t(6;14)(p22;q32), involving IGH@ as a novel recurrent translocation in 13 BCP-ALL patients. Fluorescence in situ hybridization and long-distance inverse pol...
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متن کامل
diversity of t-cell receptor gene rearrangements in south indian patients with common acute lymphoblastic leukemia
background: precursor b-acute lymphoblastic leukemia (precursor b-all) oc-curs due to the uncontrolled proliferation of b-lymphoid precursors arrested at a par-ticular stage of b-cell development. precursor-b-all is classified mainly into pro-b-all, common-all and pre-b-all. the common acute lymphoblastic antigen cd10 is the marker for common-all. objective: this study was aimed to examine the ...
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ژورنال
عنوان ژورنال: South African journal of oncology
سال: 2021
ISSN: ['2518-8704', '2523-0646']
DOI: https://doi.org/10.4102/sajo.v5i0.179